Dose Finding By The Continual Reassessment Method Cheung, Y

 
Poster un nouveau sujet   Répondre au sujet    Les lutins Insomniak Index du Forum :: Partie Publique :: Demande d'ambassade
Sujet précédent :: Sujet suivant  
Auteur Message
denzicaitl


Hors ligne

Inscrit le: 14 Avr 2016
Messages: 116
Localisation: Strossburi

MessagePosté le: Sam 21 Mai - 04:50 (2016)    Sujet du message: Dose Finding By The Continual Reassessment Method Cheung, Y Répondre en citant




Dose Finding By The Continual Reassessment Method Cheung, Ying Kuen|| > urlin.us/2c0lk





Bethesda:..National..Cancer..Institute;..2003For.the.MCMC,.a.burn-in.of.1000.with.10.000.iterations.keeping.every.fifth.sample.provides.adequate.convergenceThis.implies.that,.F&#x003b2;(&#x003b4;1)&#x02212;1(pT+&#x003b4;1)<F&#x003b2;(&#x003b4;2)&#x02212;1(pT+&#x003b4;2).where.F(dv,&#x003b2;(&#x003b4;k)).=.pT.&#x02212;.&#x003b4;k.for.k.=.1,.2.since.F(d,&#x003b2;).is.strictly.increasing.in.d.and.F.&#x02212;1(p,.&#x003b2;).is.strictly.increasing.in.&#x003b2;Biometrics[PubMed]Yuan.Z,.Chappell.R,.Bailey.HNCBISkip...to...main...contentSkip...to...navigationResourcesAll...ResourcesChemicals...&...BioassaysBioSystemsPubChem...BioAssayPubChem...CompoundPubChem...Structure...SearchPubChem...SubstanceAll...Chemicals...&...Bioassays...Resources.DNA...&...RNABLAST...(Basic...Local...Alignment...Search...Tool)BLAST...(Stand-alone)E-UtilitiesGenBankGenBank:...BankItGenBank:...SequinGenBank:...tbl2asnGenome...WorkbenchInfluenza...VirusNucleotide...DatabasePopSetPrimer-BLASTProSplignReference...Sequence...(RefSeq)RefSeqGeneSequence...Read...Archive...(SRA)SplignTrace...ArchiveUniGeneAll...DNA...&...RNA...Resources.Data...&...SoftwareBLAST...(Basic...Local...Alignment...Search...Tool)BLAST...(Stand-alone)Cn3DConserved...Domain...Search...Service...(CD...Search)E-UtilitiesGenBank:...BankItGenBank:...SequinGenBank:...tbl2asnGenome...ProtMapGenome...WorkbenchPrimer-BLASTProSplignPubChem...Structure...SearchSNP...Submission...ToolSplignVector...Alignment...Search...Tool...(VAST)All...Data...&...Software...Resources.Domains...&...StructuresBioSystemsCn3DConserved...Domain...Database...(CDD)Conserved...Domain...Search...Service...(CD...Search)Structure...(Molecular...Modeling...Database)Vector...Alignment...Search...Tool...(VAST)All...Domains...&...Structures...Resources.Genes...&...ExpressionBioSystemsDatabase...of...Genotypes...and...Phenotypes...(dbGaP)E-UtilitiesGeneGene...Expression...Omnibus...(GEO)...Database...Gene...Expression...Omnibus...(GEO)...DatasetsGene...Expression...Omnibus...(GEO)...ProfilesGenome...WorkbenchHomoloGeneMap...ViewerOnline...Mendelian...Inheritance...in...Man...(OMIM)RefSeqGeneUniGeneAll...Genes...&...Expression...Resources.Genetics...&...MedicineBookshelfDatabase...of...Genotypes...and...Phenotypes...(dbGaP)Genetic...Testing...RegistryInfluenza...VirusMap...ViewerOnline...Mendelian...Inheritance...in...Man...(OMIM)PubMedPubMed...Central...(PMC)PubMed...Clinical...QueriesRefSeqGeneAll...Genetics...&...Medicine...Resources.Genomes...&...MapsDatabase...of...Genomic...Structural...Variation...(dbVar)GenBank:...tbl2asnGenomeGenome...ProjectGenome...ProtMapGenome...WorkbenchInfluenza...VirusMap...ViewerNucleotide...DatabasePopSetProSplignSequence...Read...Archive...(SRA)SplignTrace...ArchiveAll...Genomes...&...Maps...Resources.HomologyBLAST...(Basic...Local...Alignment...Search...Tool)BLAST...(Stand-alone)BLAST...Link...(BLink)Conserved...Domain...Database...(CDD)Conserved...Domain...Search...Service...(CD...Search)Genome...ProtMapHomoloGeneProtein...ClustersAll...Homology...Resources.LiteratureBookshelfE-UtilitiesJournals...in...NCBI...DatabasesMeSH...DatabaseNCBI...HandbookNCBI...Help...ManualNCBI...NewsPubMedPubMed...Central...(PMC)PubMed...Clinical...QueriesPubMed...HealthAll...Literature...Resources.ProteinsBioSystemsBLAST...(Basic...Local...Alignment...Search...Tool)BLAST...(Stand-alone)BLAST...Link...(BLink)Conserved...Domain...Database...(CDD)Conserved...Domain...Search...Service...(CD...Search)E-UtilitiesProSplignProtein...ClustersProtein...DatabaseReference...Sequence...(RefSeq)All...Proteins...Resources.Sequence...AnalysisBLAST...(Basic...Local...Alignment...Search...Tool)BLAST...(Stand-alone)BLAST...Link...(BLink)Conserved...Domain...Search...Service...(CD...Search)Genome...ProtMapGenome...WorkbenchInfluenza...VirusPrimer-BLASTProSplignSplignAll...Sequence...Analysis...Resources.TaxonomyTaxonomyTaxonomy...BrowserTaxonomy...Common...TreeAll...Taxonomy...Resources.Training...&...TutorialsNCBI...Education...PageNCBI...HandbookNCBI...Help...ManualNCBI...NewsAll...Training...&...Tutorials...Resources.VariationDatabase...of...Genomic...Structural...Variation...(dbVar)Database...of...Genotypes...and...Phenotypes...(dbGaP)Database...of...Single...Nucleotide...Polymorphisms...(dbSNP)SNP...Submission...ToolAll...Variation...Resources.How...ToAll...How...ToChemicals...&...BioassaysDNA...&...RNAData...&...SoftwareDomains...&...StructuresGenes...&...ExpressionGenetics...&...MedicineGenomes...&...MapsHomologyLiteratureProteinsSequence...AnalysisTaxonomyTraining...&...TutorialsVariationAbout...NCBI...AccesskeysMy...NCBISign...in...to...NCBISign...OutThe..highest..average..PCS..for..an..odds..ratio..of..5..was..79.0%..which..occurred..when..&#x003b4;..is..0.12We..provide..the..optimal..&#x003b4;..for..the..most..common..scenarios..encountered..assuming..an..empiric..dose..toxicity..model..along..with..an..example..that..illustrates..the..way..to..use..the..tablesWe...obtained...the...joint...probability...distributions...of...the...2...toxicities...from...the...2...marginals...under...independenceThe..range..of..&#x003b4;..is..0.10..to..0.14The..initial..guesses..obtained..using..the..Extended..Algorithm..correspond..to..&#x003b4;..=..0.04Elkind.MS,.Sacco.RL,.MacArthur.RB,.et.alThe.treatment.was.administered.to.33.patients.for.30.days,.with.dose.escalation.for.lovastatin.occurring.in.the.first.3.days.and.all.patients.receiving.20.mg/day.for.the.following.27.daysFor...example,...in...the...lymphoma...trial,...if...&#x003b4;...=...0.03...then...P(&#x003b2;...&#x02208;...Hi)...for...i...=...1,&#x02026;,5...are...(0.42,...0.06,...0.06,...0.06,...0.40)491)Lunn...DJ,...Thomas...A,...Best...N,...Spiegelhalter...DThis...conclusion...is...based...on...an...exponential...prior...&#x003c0;(&#x003b2;)...=...exp(&#x02212;&#x003b2;)...and...a...particular...choice...of...the...initial...guesses...of...DLT...probabilities2010;97:1091210.05,.0.10,.0.25,.0.35,.0.50,.0.70).along.with.a.logistic.with.a=3.and.a=1.as.the.dose.toxicity.model.and.then.using.the.initial.guess.corresponding.to.a.&#x003b4;.of.0.08.along.with.an.empiric.dose.toxicity.modelThe...optimal...&#x003b4;...will...be...different...if...the...dose...toxicity...model...is...assumed...to...be...logisticCheung..YK;6(3):227-238.MeSH.Terms,.Substances,.Grant.SupportMeSH.TermsAlgorithmsCalibrationClinical.Trials.as.Topic/methods*Dose-Response.Relationship,.DrugDrug-Related.Side.Effects.and.Adverse.ReactionsHumansModels,.Theoretical*Pharmaceutical.Preparations/administration.&.dosage*SubstancesPharmaceutical.PreparationsGrant.SupportR01.NS055809/NS/NINDS.NIH.HHS/United.StatesR01.NS055809-04/NS/NINDS.NIH.HHS/United.StatesLinkOut.-.more.resourcesFull.Text.SourcesHighWire.-.PDFEurope.PubMed.Central.-.Author.ManuscriptPubMed.Central.-.Author.ManuscriptPubMed.Central.Canada.-.Author.ManuscriptMedicalClinical.Trials.-.MedlinePlus.Health.InformationMedicines.-.MedlinePlus.Health.InformationPubMed.Commons.home.PubMed.Commons.0.commentsHow.to.join.PubMed.CommonsHow.to.cite.this.comment:.[PubMed]Simon...R,...Freidlin...B,...Rubinstein...L,...Arbuck...SG,...Collins...J,...Christian...MCThe.calibration.is.based.on.2000.simulationsSommarioThe...CRM...did...not...allow...dose...skipping...during...escalationFor.example,.given.a.&#x003b4;.value.of.0.05.which.corresponds.to.an.indifference.interval.of.(0.20,.0.30),.we.can.calculate.the.initial.guesses.of.the.probabilities.of.DLT.using.equations.(3).and.(4).as.follow:.d1=p1=exp(log(0.20)log(0.157)log(0.30))=0.084d2=p2=exp(log(0.20)log(0.25)log(0.30))=0.157d4=p4=exp(log(0.30)log(0.25)log(0.30))=0.355d5=p5=exp(log(0.30)log(0.355)log(0.20))=0.460.Thus,.the.initial.guesses.of.the.probabilities.of.DLT.at.each.dose.are.0.084,.0.157,.0.250,.0.355,.0.460.respectively,.and.they.yield.an.indifference.interval.of.(0.20,.0.30).The.results.are.displayed.in.Figure.1The.book.includes.examples.of.real.clinical.trials.data.to.illustrate.the.calibration.techniques.and.shows.how.R.can.be.used.to.carry.out.the.techniquesThe.proof.for.1.&#x02212;.v.&#x02264;.i.&#x02264;.&#x02212;1.is.similar.and.thus.omittedAs..in..the..CRM,..it..is..important..to..calibrate..the..design..to..obtain..good..operating..characteristics..under..a..variety..of..real..life..scenariosThe.MTD.was.defined.as.the.dose.associated.with.a.target.probability.of.DLT.of.0.10,.where.DLT.was.defined.as.liver.or.muscle.toxicity.based.on.changes.in.laboratory.markers.or.symptomsAbout..Us..Corporate..History..Careers..at..CRC..Press..Conference..Schedule..Frequently..Asked..Questions..Press..Releases..Resources..For..Authors..For..Booksellers..For..Instructors..For..Librarians..For..the..Press..For..Societies..Textbooks..Custom..Publishing..CRCnetBASE..Featured..Authors..Search..Advanced..Search....Or..Browse..by..Subject..Agricultural..Science..Biomedical..Science..Business..&..Management..Chemistry..Computer..Science..&..Engineering..Energy..&..Clean..Technology..Engineering..-..Chemical..Engineering..-..Civil..Engineering..-..Electrical..Engineering..-..Environmental..Engineering..-..General..Engineering..-..Industrial..&..Manufacturing..Engineering..-..Mechanical..Engineering..-..Mining..Environmental..Science..Ergonomics..&..Human..Factors..Food..&..Culinary..Science..Forensics..&..Criminal..Justice..Games..&..Animation..Geoscience..Healthcare..Homeland..Security..Information..Technology..Life..Science..Materials..Science..Mathematics..Medicine..Nanoscience..&..Technology..Nutrition..Occupational..Health..&..Safety..Pharmaceutical..Science..Physics..Polymer..Science..Public..Administration..&..Public..Policy..Statistics..Veterinary..Medicine..Water..Science..&..Engineering..Shipping...Region...Afghanistan...Albania...Algeria...American...Samoa...Andorra...Anguilla...Angola...Antarctica...Antigua...And...Barbuda...Argentina...Armenia...Aruba...Austria...Australia...Azerbaijan...Bahamas...Bahrain...Bangladesh...Barbados...Belize...Belgium...Belarus...Benin...Bermuda...Bhutan...Bolivia...Bosnia...And...Herzegovina...Botswana...Bouvet...Island...Brazil...British...Indian...Ocean...Territory...Brunei...Darussalam...Bulgaria...Burundi...Burkina...Faso...Cambodia...Cameroon...Canada...Cape...Verde...Cayman...Islands...Central...African...Republic...Chad...Chile...China...Christmas...Island...Cocos...(Keeling)...Islands...Colombia...Comoros...Congo,...The...Democratic...Republic...Of...The...Congo...Cook...Islands...Costa...Rica...Croatia...Cyprus...Czech...Republic...Cte...D'ivoire...Denmark...Djibouti...Dominican...Republic...Dominica...Ecuador...Egypt...El...Salvador...Equatorial...Guinea...Eritrea...Estonia...Ethiopia...Falkland...Islands...(Malvinas)...Faroe...Islands...Fiji...Finland...France...French...Southern...Territories...French...Polynesia...French...Guiana...Gabon...Gambia...Georgia...Germany...Ghana...Gibraltar...Grenada...Greenland...Greece...Guam...Guatemala...Guadeloupe...Guernsey...Guinea-Bissau...Guinea...Guyana...Haiti...Heard...Island...And...Mcdonald...Islands...Holy...See...(Vatican...City...State)...Hong...Kong...Honduras...Hungary...Iceland...India...Indonesia...Iraq...Ireland...Isle...Of...Man...Israel...Italy...Jamaica...Japan...Jersey...Jordan...Kazakhstan...Kenya...Kiribati...Korea,...Republic...Of...Kuwait...Kyrgyzstan...Lao...People's...Democratic...Republic...Latvia...Lebanon...Lesotho...Liberia...Libyan...Arab...Jamahiriya...Liechtenstein...Lithuania...Luxembourg...Macedonia,...The...Former...Yugoslav...Republic...Of...Macao...Madagascar...Mali...Malta...Maldives...Malaysia...Malawi...Martinique...Marshall...Islands...Mauritania...Mauritius...Mayotte...Mexico...Micronesia,...Federated...States...Of...Moldova,...Republic...Of...Montserrat...Montenegro...Monaco...Mongolia...Morocco...Mozambique...Myanmar...Namibia...Nauru...Nepal...Netherlands...Netherlands...Antilles...New...Zealand...New...Caledonia...Nicaragua...Nigeria...Niger...Niue...Norway...Northern...Mariana...Islands...Norfolk...Island...Oman...Pakistan...Palau...Palestinian...Territory,...Occupied...Panama...Papua...New...Guinea...Paraguay...Peru...Philippines...Pitcairn...Poland...Portugal...Qatar...Reunion...Romania...Russian...Federation...Rwanda...Saint...Martin...Saint...Pierre...And...Miquelon...Saint...Vincent...And...The...Grenadines...Saint...Lucia...Saint...Barthlemy...Saint...Kitts...And...Nevis...Saint...Helena...Samoa...San...Marino...Sao...Tome...And...Principe...Saudi...Arabia...Senegal...Serbia...Seychelles...Sierra...Leone...Singapore...Slovakia...Slovenia...Solomon...Islands...Somalia...South...Georgia...And...The...South...Sandwich...Islands...South...Africa...Spain...Sri...Lanka...Suriname...Svalbard...And...Jan...Mayen...Swaziland...Sweden...Switzerland...Taiwan...Tajikistan...Tanzania,...United...Republic...Of...Thailand...Timor-Leste...Togo...Tokelau...Tonga...Trinidad...And...Tobago...Tunisia...Turkmenistan...Turks...And...Caicos...Islands...Turkey...Tuvalu...Uganda...Ukraine...United...States...Minor...Outlying...Islands...United...States...United...Kingdom...United...Arab...Emirates...Uruguay...Uzbekistan...Vanuatu...Venezuela...Viet...Nam...Virgin...Islands,...British...Virgin...Islands,...U.SIf..2..&#x02208;..(0.176,..3),..the..CRM..may..select..the..second..dose..as..the..MTD,..but..the..probability..of..DLT..is..close..enough..to..the..target..probability..of..DLT..that..the..investigator..would..be..indifferent..if..the..incorrect..dose..was..selectedAll...rights...reservedAll.simulations.in.this.paper.can.be.easily.performed.using.the.getprior.and.the.crmsim.function.in.the.R.package.&#x02018;dfcrm&#x02019;.[11],.[12]A.detailed.exposition.of.the.calibration.of.the.CRM.for.applied.statisticians.working.with.dose-finding.in.phase.I.trials,.the.book.focuses.on.the.R.package.dfcrm.for.the.CRM.and.its.major.variantsBiometrics[PMC...free...article]...[PubMed]62005;92(4):863873.7 f5880b0734



Revenir en haut
Publicité






MessagePosté le: Sam 21 Mai - 04:50 (2016)    Sujet du message: Publicité

PublicitéSupprimer les publicités ?
Revenir en haut
Montrer les messages depuis:   
Poster un nouveau sujet   Répondre au sujet    Les lutins Insomniak Index du Forum :: Partie Publique :: Demande d'ambassade Toutes les heures sont au format GMT + 1 Heure
Page 1 sur 1

 
Sauter vers:  

Index | Panneau d’administration | Creer un forum | Forum gratuit d’entraide | Annuaire des forums gratuits | Signaler une violation | Conditions générales d'utilisation


Powered by phpBB © 2001, 2018 phpBB Group
Traduction par : phpBB-fr.com Charcoal2 Theme © Zarron Media